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David Boutolleau Selected Research

Acyclovir (Aciclovir)

1/2022Pritelivir for recurrent aciclovir-resistant herpes simplex virus 2 infections in immunocompromised patients.
1/2022Acyclovir-Resistant Herpes Simplex Virus 1 Keratitis: A Concerning and Emerging Clinical Challenge.
10/2020[Herpes simplex virus resistance to antivirals].
1/2019Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis.
1/2018Utility of ultra-deep sequencing for detection of varicella-zoster virus antiviral resistance mutations.
7/2016Complementary assays for monitoring susceptibility of varicella-zoster virus resistance to antivirals.
8/2014Long-term follow-up of HIV-infected patients once diagnosed with acyclovir-resistant herpes simplex virus infection.
9/2013Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.
12/2012Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity.
2/2010Bipolar hypertrophic herpes: an unusual presentation of acyclovir-resistant herpes simplex type 2 in a HIV-infected patient.
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David Boutolleau Research Topics

Disease

27Infections
07/2022 - 01/2003
6COVID-19
07/2022 - 11/2020
5Herpetic Keratitis
01/2022 - 09/2013
3Pneumonia (Pneumonitis)
11/2020 - 05/2014
2Virus Diseases (Viral Diseases)
10/2020 - 11/2016
2Acquired Immunodeficiency Syndrome (AIDS)
01/2016 - 02/2009
2Herpes Simplex
08/2014 - 02/2010
2Viremia
05/2014 - 10/2011
2Herpesviridae Infections (Herpesvirus Infection)
03/2012 - 11/2009
1Keratitis
01/2022
1Common Cold
01/2022
1Meningitis
11/2021
1Herpes Zoster
11/2021
1Abscess
01/2021
1Ventilator-Associated Pneumonia
11/2020
1Critical Illness (Critically Ill)
11/2020
1Latent Infection
10/2020
1Varicella Zoster Virus Infection
01/2018
1Neoplasms (Cancer)
01/2018
1Hepatitis B
11/2016
1Cytomegalovirus Infections (Inclusion Disease)
12/2014
1Herpes Labialis (Fever Blister)
07/2014
1Human Influenza (Influenza)
05/2014
1Meningoencephalitis
12/2013
1HIV Infections (HIV Infection)
06/2012
1Chronic Kidney Failure (Chronic Renal Failure)
03/2012
1RNA Virus Infections
11/2011
1Central Nervous System Infections (Central Nervous System Infection)
11/2011
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/2011
1Acute Liver Failure (Fulminant Hepatic Failure)
06/2008
1Optic Neuritis (Retrobulbar Neuritis)
07/2007
1Encephalitis (Encephalitis, Rasmussen)
04/2006
1Coinfection
03/2006

Drug/Important Bio-Agent (IBA)

16Antiviral Agents (Antivirals)IBA
11/2021 - 09/2009
11Acyclovir (Aciclovir)FDA LinkGeneric
01/2022 - 11/2009
4FoscarnetFDA LinkGeneric
10/2020 - 11/2009
4Cidofovir (Vistide)FDA Link
10/2020 - 04/2006
4DNA (Deoxyribonucleic Acid)IBA
11/2011 - 12/2006
3Immunoglobulin G (IgG)IBA
07/2022 - 11/2020
3AntibodiesIBA
01/2022 - 10/2011
3Ganciclovir (Cytovene)FDA LinkGeneric
05/2016 - 02/2009
3ValganciclovirFDA Link
05/2016 - 02/2009
3Viral DNAIBA
04/2016 - 02/2009
2pritelivirIBA
01/2022 - 04/2014
2Immunoglobulin M (IgM)IBA
01/2022 - 11/2020
2Hydroxychloroquine (Plaquenil)FDA LinkGeneric
12/2021 - 11/2020
2DNA Primase (Primase)IBA
11/2021 - 04/2014
2LopinavirFDA Link
01/2021 - 11/2020
2Ritonavir (Norvir)FDA Link
01/2021 - 11/2020
2Biological ProductsIBA
07/2016 - 03/2006
2Pharmaceutical PreparationsIBA
12/2013 - 12/2012
1Immunoglobulin A (IgA)IBA
07/2022
1Neutralizing AntibodiesIBA
07/2022
1Biomarkers (Surrogate Marker)IBA
07/2022
1Proteins (Proteins, Gene)FDA Link
07/2022
1AntigensIBA
01/2022
1Intravenous Immunoglobulins (IVIG)FDA Link
01/2022
1Chickenpox Vaccine (Vaccine, Varicella)IBA
11/2021
1Adrenal Cortex Hormones (Corticosteroids)IBA
11/2021
1VaccinesIBA
11/2021
1CytokinesIBA
11/2021
1ASP2151IBA
11/2021
1Anti-Bacterial Agents (Antibiotics)IBA
01/2021
1Virulence Factors (Pathogenicity Factors)IBA
01/2020
1Heparitin Sulfate (Heparan Sulfate)IBA
01/2018
1Tenofovir (Viread)FDA Link
11/2015
1Antigen-Antibody Complex (Immune Complex)IBA
05/2014
1Hemagglutinins (Hemagglutinin)IBA
05/2014
1GuanosineIBA
12/2012
1penciclovir (Denavir)FDA Link
11/2009
1Phosphotransferases (Kinase)IBA
02/2009
1Codon (Codons)IBA
02/2009
1DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
03/2008

Therapy/Procedure

6Therapeutics
08/2021 - 07/2007
2Artificial Respiration (Mechanical Ventilation)
11/2020 - 05/2014
2Drug Therapy (Chemotherapy)
01/2018 - 11/2016
2Hematopoietic Stem Cell Transplantation
12/2014 - 12/2013
2Transplantation
12/2014 - 03/2012
1Heart Transplantation (Grafting, Heart)
08/2021
1Organ Transplantation
01/2018
1Art Therapy
01/2016
1Salvage Therapy
06/2012
1Kidney Transplantation
03/2012
1Stem Cell Transplantation
01/2003